期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白细胞介素-1受体拮抗剂与骨性关节炎的关系 被引量：6

Correlation between osteoarthritis and interleukin-1 receptor antagonist
下载PDF
导出
摘要 骨性关节炎(OA)是以关节软骨的合成与降解失衡导致软骨丢失为特点的慢性疾病。白细胞介素-1(IL-1)在其发病过程中发挥了重要作用,而作为IL-1特异性的天然拮抗物白细胞介素-1受体拮抗剂(IL-1Ra)越来越受到广泛的重视。作者对IL-1Ra与OA的关系作一综述。 The hallmark of osteoarthnitis（OA） is the loss of articular cartilage caused by an imbalance between cartilage synthesis and degredation over a variable period of time. IL-1 plays an important role in the course. The IL-lreceptor antagonist（IL-Ra） specific against IL-1 is becoming a pivot of wide attention. The article offers a review of the relationship between the IL-1 Ra and OA.
作者 葛广勇 赵建宁
机构地区 南京军区南京总医院南方医科大学南京临床医学院骨科
出处 《医学研究生学报》 CAS 2007年第10期1084-1087,共4页 Journal of Medical Postgraduates
基金 全军"十一五"重点攻关项目(批准号:06G043)
关键词 白细胞介素-1 白细胞介素-1受体拮抗剂 骨性关节炎 Interleukin-1 Interleukin-1 receptor antagonist Osteoarthritis
分类号 R684.3 [医药卫生—骨科学]
  • 相关文献

参考文献26

  • 1Eisenberg SP,Evans RJ,Arend UP,et al.Primary structure and functional expression from complementary DNA of a human interleukin-11 receptor antagonist[J].Nature,1990,34(25):341-346.
  • 2Diarello CA.Biologic basis for interleukin-1 in disease[J].Blood,1996,87 (6):2095 -2147.
  • 3Holtkamp GM,de Vos AF,kijlatra A,et al.Expression of multiple forms of IL-1 receptor antagonist (IL-1Ra) by human retinal pigment epithelial cells:indentification of a new IL-1 ra exon[J].Eur J Immunol,1999,29(1):215-224.
  • 4Malyak M,Smith MF Jr,Abel AA,et al.The differential production of three forms of Il-1 receptor antagonists by human neutrophics and monocytes[J].J Immunol,1998,161 (4):2004-2010.
  • 5Frisbie DD,Ghivizzani SC,Robbins PD,et al.Treatment of experimental equine osteoarthritis by in vivo delivery of the equine inteleukin-1 receptor antagonist gene[J].Gene Ther,2002,9 (1):12-20.
  • 6黄异飞,敖英芳,王梅.膝关节股骨外髁髁间侧壁软骨Ⅰ、Ⅲ型胶原和IL-1α、IL-1Ra分布的研究及其临床意义[J].中国运动医学杂志,2004,23(3):240-242. 被引量：3
  • 7王宸,李强,吴小涛,齐新生,刘松桥.白细胞介素-1受体拮抗剂对兔椎间盘髓核前列腺素和5-羟色胺代谢的影响[J].中国脊柱脊髓杂志,2004,14(1):26-28. 被引量：6
  • 8Fernandes JC,Martel-Pelleter J,Pelleter JP.The role of cytokine in osteoathritis pathopysiology[J].Biorheology,2002,39 (1-2):237 -246.
  • 9Dayerr JM,Feige U,Edwards CK,et al.Anti-interleukin-1 therapy in rheumatic diseases[J].Curr Opin Rheumatol,2001,13 (3):170-176.
  • 10Murata M,Trahan C,Hirahanshi J,et al.Intracellular interleukin-1 receptor antagoist in osteoarthritis chondrocytes[J].Clin Orthop,2003,35 (409):285-295.

二级参考文献57

  • 1邓廉夫.正常关节软骨的胶原表型与骨关节炎关节软骨的表型异常[J].国外医学（创伤与外科基本问题分册）,1996,17(3):152-155. 被引量：15
  • 2[1]Johnson LL.Arthroscopic abrasion arthroplasy:a review[J].Clin Orthop,2001,10(391):306-317.
  • 3[2]Hunt SA,Jazrawi LM,Sherman OH.Arthroscopic management of osteoarthritis of the knee[J]. J Am Acad Orthop Surg, 2002,10(5):356-363.
  • 4[3]Nixon AJ,Fortier LA,Williams J et al. Enhanced repair of extensive articular defects by insulin-like growth factor Ⅰladen fibrin composites[J].J Orthop Res,1999,17(4):475-487.
  • 5[4]Steadman JR, Miller BS, Karas SG. The microfracture technique in the treatment of full-thickness chondral lesions of the knee in National Football League players[J]. J Knee Surg, 2003, 16(2):83-86.
  • 6[5]Bentley G, Biant LC, Carrington RW et al. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee[J]. J Bone Joint Surg Br, 2003, 85(2):223-230.
  • 7[6]Minas T,Peterson L.Chondrocyte transplantation[J].Oper Tech Orthop,1997,7(4):323-333.
  • 8[7]Peterson L. Articular cartilage injuries treated with autologous chondrocyte transplantation in the human knee[J]. Acta Orthop Belg, 1996,62(Suppl):196-200.
  • 9[8]Messner K, Gillquist J. Cartilage repair: a critical review[J]. Acta Orthop Scand , 1996,67(5):523-529.
  • 10[9]Hangody L,Feczko P,Kemeny D et al. Autologous osteochondral mosaicplasty for the treatment of full thickness cartilage defects of the knee and ankle[J].Clin Orthop ,2001,391(Suppl):328-337.

共引文献37

同被引文献66

引证文献6

二级引证文献55

医学研究生学报
2007年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部