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MTS1 基因产物 P16 蛋白在膀胱移行细胞癌中的表达 被引量:1

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摘要 MTS1基因产物P16蛋白在膀胱移行细胞癌中的表达陈强王新生董胜国李玉军孙显露申东亮MTS1(multipletumorsuppressor1)因子是新近发现的一种多肿瘤抑制基因,能负性调节细胞周期,并与多种人类肿瘤的发生、发展密切相关[1]。为探讨...
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 1997年第4期240-240,共1页 Chinese Journal of Urology
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  • 1袁建林,王剑波,于茂生,李青,辛建国,郭炜.抑癌基因P16在膀胱肿瘤中的表达及意义[J].中华泌尿外科杂志,1995,16(12):722-724. 被引量:19
  • 2Kamb A, Gruis NA. Weaver-Feldhaus J,et sl. A cell cycle regulator ,potentially involved in genesis of many tumor types. Science, 1994, 264:436.
  • 3Moborl T,Miura K, Wu DJ, et al. Deletions of the cyclin dependent kinase-4 inhibitor gene in multiple human cancer. Nature (Lond), 1994,366:753.
  • 4Liu Q, Neuhausen S, Mcclure M, et al. CDKN2 (MTS1) tumor suppressor gene mutations in human tumor cell lines. Oncogene, 1995,10:1061.
  • 5Xu-HJ,Cairus P,Hu SX ,et al, Loss of Rb protein expressioa in primary bladder cancer correlates with loss of heterozygosity at the Rb, Locus and tumor progression, Int J Cancer, 1993;53:781.
  • 6Spruck CHI. Gonzaleaz-Zulueta M, Shibata A, et al. P16 gene in uncultured tumors. Science, (Washington Dc), 1994;64:183.
  • 7Walker DG Dan W. popovic EA, et al. Homozygous delection of the multinle tumor suppressor gene I in the progression of human astcocyromas. Cancer Res, 1995,55: 20.
  • 8Caldas C,Hahn SA,Dacosta LT,et al. Fxenquent amostic.mutations and homozygous deletios of tha p16;(MTS1)gene in pancreatic adenocarcinoma. Nature Gent, 1994,8:27.
  • 9Serrano M, OJ,Beach D, Anew regulatory motic in cellcycle control causing specific inhibition of cyclin/CDK4.Nature (Lond), 1993,366:704.
  • 10Reed JA, Loganzo F, Shca CR, et al. Loss of expression of the p16/cylin-dependent kinase inhibitor 2 tumor suppressor gene in metanocytic Lessions correlates with invasive stage of tumor progression. Cancer Res. 1995,55:2713.

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