鼻咽癌组织中C-erb B-2的表达与血管生成的关系

Expression of C-erb B-2 and its relation to angiogenesis in nasopharyngeal carcinoma

目的探讨C-erbB-2在鼻咽癌组织中的表达与肿瘤血管形成的关系。方法应用免疫组化方法检测77例鼻咽癌患者活检石蜡包埋标本的C-erbB-2、血管内皮生长因子的表达,应用因子相关抗原(F8)显示血管内皮细胞,根据F8阳性的血管内皮细胞计数来测定肿瘤微血管密度。结果C-erbB-2在鼻咽癌组织中的阳性表达率为36.36%(28/77),血管内皮生长因子在鼻咽癌组织中的阳性表达率为32.48%(25/77),血管内皮生长因子表达阳性率也越高,C-erbB-2表达阳性者微血管密度值也高(P=0.648>0.05)。结论C-erbB-2可能在鼻咽癌血管生成中起到促进作用。

Objective To investigate the association of C-erb B-2 expression with angiogenesis in nasopharygeal carcinoma. Methods Seventy-seven specimens of nasopharygeal carcinoma were examined immunohistochemically for protein expressions of C-erb B-2 and vascular endothelial growth factor （VEGF）, and the microvessel density （MVD） was determined by immunostaining of the endothelial cells for factor Ⅷ-related antigen （F8）, Results Positive C-erb B-2 immunostaining was observed in 36.36% （28/77） of the nasopharygeal carcinoma tissues, which had a VEGF positivity rate of 32,48% （25/77）. High positivity rate of C-erg B-2 was associated with high positivity rate of VEGF and high MVD （P〈0.05）. Conclusion The expression of C-erb B-2 may contribute to angiogenesis in nasopharygeal carcinoma.