肾上腺肿瘤P53及c-myc癌基因表达研究

Expression of P53 and c myc gene in human adrenal tumors

为探讨肾上腺肿瘤发病机理，为鉴别肿瘤良恶性及其分级分期提供依据，收集３４例肾上腺恶性肿瘤应用ＳＰ法作Ｐ５３及ｃｍｙｃ免疫组化检测，并与２５例肾上腺良性瘤及１２例非瘤肾上腺组织对比。结果显示：肾上腺恶性瘤Ｐ５３阳性率４７１％，良性瘤８０％，非瘤组织无表达；肾上腺恶性肿瘤ｃｍｙｃ阳性率３８２％，良性瘤及非瘤组织无表达；Ｐ５３表达与肾上腺恶性瘤临床分期相关，ｃｍｙｃ与其临床分期不相关，均可用于良恶性瘤鉴别。

Detection of P53 and c myc with immunohistochemical technique were carried out for 34 surgical specimens of malignant tumor of adrenal gland,25 adrenal benign tumors and in 12 adrenal tissues free of tumor.The positive rate of P53 expression was 47.1% in adrenal malignant tumors,8 0% in benign tumors but none in adrenal tissues free of tumor.c myc expression was positive in 38.2% of malignant tumors but none in either benign tumors or adrenal tissues free of tumor.P53 expression was related to the clinical stage of adrenal maligmant tumors while c myc did not.The detection of the two might help in the differentiation of malignant from benign adrenal tumors.