p53基因联合化疗治疗难治性上颌窦癌

Treatment of Refractory Carcinoma of Maxillary Sinus by Combination of p53 Gene and Chemotherapy

目的探讨p53抑癌基因在难治性上颌窦癌治疗中的作用。方法采用局部瘤内注射重组人P53腺病毒注射液,联合紫杉醇+卡铂化疗,每3周1次,共3个周期。结果3个周期治疗后,MRI显示肿瘤完全消失。除中等度发热外,未见其他不良反应。结论p53基因可显著增强上颌窦癌化疗敏感性和逆转癌细胞耐药,可作为难治性上颌窦癌治疗选择。

Objective To evaluate the role of p53 gene in treatment of refractory carcinoma of maxillary sinus. Methods The re- combinant human adenovirus-p53 injections （rAd - 53） was used to treat one patient by internal tumor injection. Chemotherapy with regimen of paclitael plus carboplatin was also administered after two days of rAd - 53 injection every three weeks. Results The tumor of maxillary sinus was disappeared after three cycles of treatment. The side - effect with mild fever was tolerable and easily disposable. Con- clusions The rAd - 53 should be a good choice in treatment of refractory carcinoma of maxillary sinus.