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基质金属蛋白酶与子宫内膜癌

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摘要 1基质金属蛋白酶的概述 基质金属蛋白酶(matrix metalloproteinases,MMPs)是一个在结构上具有极大同源性的Zn^2+赖性内源性蛋白水解酶家族,其主要功能为降解细胞外基质(extracellulor matrix,ECM)成分,在细胞外基质(ECM)的动态平衡、组织重塑、修复、肿瘤侵袭转移等生理及病理过程中发挥重要作用。目前已证实MMPs在几乎机体各种组织的发育和修复、肿瘤发生发展、炎症反应等过程中发挥着重要的作用,已愈来愈引起人们的重视。
作者 刘瑞枝
出处 《中国医药导刊》 2007年第5期409-413,共5页 Chinese Journal of Medicinal Guide
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