分泌性中耳炎患者血清、中耳积液补体和免疫复合物含量测定

Determination of complements in serum and middle ear effusion of the patients with secretory otitis media

20例（20耳）分泌性中耳炎患者血清与对照组血清比较，CS、C1－INH含量明显增高，C9、B因子（Bf）含量明显降低，免疫复合物（IC）含量明显升高。患者的中耳积液与血清比较，C3、C4、C5含量明显降低，Bf含量明显增高，IC含量明显增高，提示补体对IC清除等功能降低，有可能引起IC沉积在中耳粘膜，从而导致毛细血管通透性增加，出现中耳积液。

Complements in serum and middle ear effusion were determined in 20 patients with secretory otitis media,and compared with those in the normal controls. The C5 and C1 INH in serum of the patients were significantly higher. On the contrary,C, and B factor (Bf) were significantly lower,and the circulatory immunocomplex was also higher. In patients with secretory otitis media,the middle ear effusion levels of C3,C4 and C5 were significantly lower,and Bf and immunocomplex were significantly higher than those in serum. The results suggest that the ability of complements in clearing immunocomplex is low. Therefore,the immunocomplex may deposit in the mucosa of the middle ear. Thus the permeability of capillary will be increased,and the middle ear effusion occurs.