睑缘炎的临床研究(英文)

Clinical research on blepharitis

目的:讨论睑缘炎的临床表现、分型、诊断、发病机制、并发症以及治疗。方法:本研究包括在眼科门诊通过裂隙灯检查确诊为睑缘炎的患者300例,针对每位患者完成一份调查问卷,在了解患者患病原因的基础上给予治疗。通过随访评价患者的治疗效果和并发症。结果:本研究中,脂溢性睑缘炎多表现为鳞屑样病变(62.5%),但感染型或混合型睑缘炎多表现为溃疡样病变(P<0.001)。此外,脂溢性睑缘炎的病程多为慢性,而感染型病程多为急性(P<0.001)。由不同类型睑缘炎而引起麦粒肿、霰粒肿、上皮型角膜炎、结膜炎及干眼症等并发症的几率不同(P<0.05)。其中,干眼症和上皮型角膜炎的临床病程多为慢性病程(P<0.05)。一些潜在的全身疾病如脂溢性皮炎、特异性皮炎、糖尿病、过敏、红斑痤疮等与睑缘炎的发生之间有密切的关系。结论:睑缘炎是眼科的常见疾病,需要注意预防该病的并发症。

AIM：To investigate clinical presentation,classification,diagnosis,pathogenesis,complication and treatment of blepharitis.METHODS：In this study,300 patients referred to general eye clinic have been chosen with diagnosis of blepharitis by Haag-streit slit-lamp examination.A questionnaire was filled in for patient with blepharitis.Then,the treatment of out-patient cases based on the causes of the condition was started.Patients were followed up and evaluated with respect to the results and complications of the treatment.RESULTS：The most common form of lesion in seborrheic dermatitis was squamous（62.5%） but ulcerative lesions was the most common in infectious and mixed types（P 〈0.001） .Also,Seborrheic blepharitis mostly had chronic clinical course but infectious type commonly was acute（P 〈0.001） .A significant difference was found between the cause of blepharitis and incidence of complications including hordeolum,chalazia,epithelial keratitis,conjunctivitis,dry eye（P 〈0.05） .Moreover,There was a significant difference between clinical course of disease and complications such as dry eye and epithelial keratitis（P 〈0.05） .There was a close relationship between the underlying diseases including seborrheic dermatitis,atopic dermatitis,diabetes mellitus,allergy,acne rosacea and the cause of blepharitis（P 〈0.05） .CONCLUSION：The blepharitis is one of the most common problems in general ophthalmology and needs attention to prevent the complications.