中药治疗青光眼疗效及安全性的文献系统评价

Efficacy and safety of traditional Chinese medicine in treating glaucoma:a systematic review

目的:系统评价分析中药治疗青光眼的有效性和不良反应。方法:检索Medline(1966/2006),EMBASE(1974/2006),中国生物医学文献数据库1978/2006,中文科技期刊全文数据库1977/2006,和中文学术期刊全文数据库1994/2006;并手工检索相关领域杂志。纳入标准以确诊为青光眼患者为研究对象、比较中医药与其它疗法疗效的随机或半随机对照试验,评价纳入研究的质量,并用RevMan4.2.9版软件进行Meta分析。结果:共纳入19篇文献,共1202例1651眼。部分中药或中西医结合治疗对改善或恢复青光眼患者的视野损害,可能有一定疗效,但是这种疗效具有选择性。对眼压因研究数较少或文献质量低尚无法确定,对视力有部分研究表明中药对青光眼视力的改善无意义,中药治疗未发现明显的副作用。结论:中药治疗青光眼有一定的疗效,但证据十分有限。

AIM：To assess the efficacy and adverse side effects of traditional Chinese medicine in the treatment of glaucoma. METHODS：To search studies which belong to randomized controlled trial design and which were about glaucoma treated with traditional Chinese medicine,based on electronic database,including MEDLINE（1966-2006）,EMBASE（1974-2006）,CBM disc（ 1978-2006 ）,CNKI（1977-2006）,and CMCC（ 1994-2006,and hand search some related journals.The quality was evaluated and meta-analysis was conducted by software RevMan 4.2.9. RESULTS：We screened 19 studies including 1 202 cases（1 651 eyes）.Some Chinese medicine or integrated Chinese and western medicine may be effective for improving the impairment of visual field,but the action had selectivity.There was no confirmed evidence for the Chinese medicine decreasing intraocular tension because of the small number of studies.Some studies showed that the Chinese medicine had nonsense in improving the visual acuity,but severe adverse effects were not found. CONCLUSION：Some Chinese medicine may be effective for treating glaucoma,but more randomized controlled trials of high quality are required due to the limited evidence.