灯盏花素抗小鼠脑缺氧作用

Protective Effects of Breviscapine on Cerebral Hypoxia in Mice

目的研究灯盏花素(Breviscapine)对小鼠脑缺氧的保护作用。方法10,20 mg/kg灯盏花素连续灌胃(Intragastric infusion,ig)小鼠7 d,各组小鼠分别腹腔注射(Introperitoneal injection,ip)200 mg/kg NaNO2或断头,记录小鼠ip NaNO2后存活时间和断头后张口呼吸的持续时间。结果10,20 mg/kg灯盏花素使ip 200 mg/kg NaNO2小鼠的存活时间比空白对照组延长83.9%和4.93%;10,20 mg/kg灯盏花素两个剂量组小鼠断头后张口呼吸的持续时间分别是空白对照组的1.60和1.30倍。结论灯盏花素对小鼠ip NaNO2和断头引起的脑缺氧具有保护作用。

bjective To study the protective effects of breviseapine on cerebral hypoxia in mice. Methods The protective effects on cerebral hypoxia were investigated on survival time after ip 200 mg/kg NaNO2 and gasping duration after decapitation in mice following 7d consecutive oral administration of breviscapine （ 10,20 mg/kg, ig）. Results Administration of breviscapine （ 10 mg/kg, ig） for 7 d could significantly prolong survival time after ip NaNO2 in mice. Compared with control group, the survival time after ip NaNO2 was prolonged 83.9 % and 4.93 %. Administration of breviscapine （10,20 mg/kg, ip） for 7d could significantly prolong gasping duration after decapitation in mice. The gasping duration after decapitation of the two experiment groups were found l. 60 and 1.30 times of the control group respectively. Conclusion Breviseapine has significant protective effects on cerebral hypoxia in mice.