蝙蝠葛酚性碱对实验性脑缺血血流动力学的影响

Effect of Phenolic Alkaloids from Menispermun dauricum on Hemodynamics in Experimental Cerebral Ischemia

目的观察蝙蝠葛酚性碱(PAMD)对大鼠血流动力学的影响,进一步探讨其保护脑缺血的作用机制。方法采用结扎颈外动脉的方法,观察PAMD对大鼠脑血流量、脑血管阻力、血压、心率等的影响。结果PAMD可增加脑血流量,降低脑血管阻力,对心脏功能无明显影响。结论PAMD对脑缺血的保护作用与其增加脑血流量有关。

Objective To investigate the effect of phenolic alkaloids from Menispermun dauricum （PAMD） on hemodynamics in rat and explore the mechanism of action for cerebral ischemia. Methods The external carotid artery of rat was ligated to observe the effect of PAMD on cerebral blood flow（CBF） .cerebral vascular resistance（CVR） .blood pressure（BP） and heart rate（HR）. Results PAMD could increase CBF and decrease CVR, but had no effect of cardiac function. Conclusion PAMD pocesses protective action on cerebral ischemia and the mechanism of action is related to the increase of CBF and the decrease of CVR. Increase of CBF may be one of the protection mechanism