急性冠脉综合征患者血清同型半胱氨酸和hs-CRP的相关性

Correlation between homocysteine level and hs-CRP level in patients with acute coronary syndrome

目的:探讨急性冠脉综合征(ACS)患者血清同型半胱氨酸水平的变化,评价其与高敏C反应蛋白(hs-CRP)的关系。方法:用免疫比浊透视法测定60例ACS患者和30例对照组血清中hs-CRP水平,以循环酶法测定血清同型半胱氨酸(Hcy)水平。结果:ACS组Hcy水平[(16.75±6.40)mg/L]明显高于对照组[(13.70±6.60)mg/L],P<0.05,AMI组的hs-CRP和Hcy水平明显高于UAP组(P<0.05),且ACS组血清Hcy水平升高[(16.75±6.40)mg/L]时,患者血清hs-CRP水平[(4.475±16.09)mg/L]也相应升高,两者之间呈正相关(r=0.444,P<0.01)。结论:血清同型半胱氨酸水平升高与心肌损伤程度有关,且可能通过hs-CRP加重心肌损伤。

Objective： To evaluate the plasma homocysteine and hs-CRP levels and their relation in patients with acute coronary syndrome （ACS）. Methods： The Hcy and hs-CRP levels were measured in 60 ACS patients and 30 normal. Results： The levels of plasma Hcy and hs-CRP were significantly increased in ACS patients compared with control group （P〈0.05）. The plasma hs-CRP and Hcy levels increased in AMI group compared with those of UAP group （P〈0.05） . The correlation between homocysteine level and hs-CRP level in ACS patients was positive （r=0. 444, P〈0.01）. While there was no correlation between hs-CRP level and Hcy levels in control group （P〉0.05）. Conclusion： Homocysteine may play an important role in the occurrence of ACS by mediating hs-CRP expression as an inflammatory medium.