嗜铬细胞瘤患者血浆醛固酮浓度的变化

Plasma aldosterone concentration changes in patients with pheochromocytoma

目的:探讨嗜铬细胞瘤患者血浆醛固酮浓度的变化特点。方法:回顾性分析我院近5年经手术病理证实或临床确诊的21例嗜铬细胞瘤患者的临床资料,并选择年龄、性别相匹配的同期住院确诊的原发性高血压患者21例,通过配对比较,研究嗜铬细胞瘤患者血浆立位、卧位醛固酮浓度的变化特点。结果:(1)嗜铬细胞瘤患者与原发性高血压患者入院时的收缩压及舒张压水平均无明显差别(P>0.05);(2)嗜铬细胞瘤患者血浆立位、卧位醛固酮浓度均高于原发性高血压患者(P<0.05)。结论:嗜铬细胞瘤患者血浆立位、卧位醛固酮浓度升高,对嗜铬细胞瘤的定性诊断具有一定的价值。

Objective： To investigate the changes of plasma aldosterone concentration in patients with phaochromocytoma. Methods： Plasma aldosterone concentrations were detected by radio-immunoassay. Blood samples were acquired in the morning when patients were stay in bed and after 2 h activity. Results： （1） The levels of systolic and diastolic blood pressure had no difference between patients with phaochromocytoma and essential hypertension （EH） ; （2） Both concentrations of plasma aldosterone of upright and stay in bed were higher in patients with phaochromocytoma than that of EH patients （P〈0.05）. Conclusion： The concentration of plasma aldosterone is higher in patients with phaochromocytoma than that of essential hypertension patient. It is valuable in diagnosis of phaochromocytoma.