雪莲细胞培养物对大鼠血液流变学的影响

Effect of cell cultures of saussurea medusa on hemorheology in rats

目的：探讨水母雪莲细胞培养物对大鼠血液流变学的影响。方法：将50只雄性SD大鼠均分为5组：对照组（A组）、模型组（B组）、低剂量组（C组）和中剂量组（D组）和高剂量组（E组）。A组给予生理盐水,C组、D组、E组分别给予水母雪莲细胞培养物0.25g/kg、0.5g/kg、1g/kg。第7 d皮下注射肾上腺素,次日采血测定全血粘度和红细胞功能指标。结果：给予水母雪莲细胞培养物的大鼠的观察指标好于模型组,尤以高剂量显著（P〈0.05-〈0.001）。结论：水母雪莲细胞培养物具有改善大鼠血循环的作用。

Objective： To investigate the effects of cell cultures of saussurea medusa （CCSM） on hemorheology in rats. Methods： A total of 50 SD male rats were averagely divided into 5 groups： control group （group A）, model group （group B）, low dose group （group C）, middle dose group （group D） and high dose group （group E） . Group A was fed with saline. Rats in group C, D, E were given CCSM 0.25g/kg, 0.5g/kg, lg/kg respectively. Adrenaline was injected at the 7th day. Blood was sampled for measuring whole blood viscosity and red blood cell functions. Results： The parameters in rats who were given CCSM were better than those in model group, especially for rats in high dose group （P〈0.05-〈0.01）. Conclusion： CCSM can ameliorate hemorheology in rats.