重度颅脑损伤引发肺水肿超微结构改变的观察

An ultrastructure study on lung edema caused by severe brain injury

目的观察重度颅脑损伤引发肺水肿超微结构的改变。方法复制Marmarou脑损伤大鼠模型,分别测量手术对照组和各损伤组肺含水量,对肺组织进行光镜和电镜观察。结果与手术对照组相比,各损伤组肺含水量明显增高且差异具有统计学意义;光镜下观察毛细血管扩张充血,肺泡水肿明显;电镜下毛细血管内皮细胞和肺泡上皮细胞变性、坏死,呼吸膜结构破坏。结论重度颅脑损伤可导致肺泡和毛细血管结构严重破坏,是神经源性肺水肿发病的解剖基础。

Objective To study the ultrastructure alterations in lung edema caused by severe brain injury. Methods Marmarou＇ s brain injury rat model was developed. The pulmonary water content in different groups was measured. The lung tissues were examined by optic microscopy （OM） and eletron microscopy（EM）. Results The pulmonary water contents in severe brain injury groups were higher than those control groups.In the severe brain injury groups,the blood capillaries were dilatatied and congested, the lung alveoli were edema fous as observed by OM. The capillary endothelial cells and the alveolar epithelial cells were degeneratied and necrotic, and the structure of respiratory membrane was damaged as seen by EM. Conclusions In severe brain injury the lung alveolis and the blood capillaries are damaged, which is the anatomical foundation of neurogenic pulmonary edema.