期刊文献+

细胞凋亡的放射性核素分子功能显像应用进展 被引量:8

Application and Progression of cell apoptosis imaging with radionuclide tracing
原文传递
导出
摘要 近几年,细胞凋亡体内检测技术发展迅速,其中最富发展前景的是核素示踪细胞凋亡显像技术,它以无创性、早期性、定量性等优势独树一帜,具有广泛的应用价值。 Recently, molecular imaging technologies detecting cell apoptosis in vivo are developing rapidly. The one of the most promising techniques to detect apoptosis in vivo is radionuclide imaging with radiolabeled annexin V. Due to the non-invasiveness, quantitation and other advantages, radionuclide tracing apoptotic imaging in vivo, which potentially has numerous valuable applications, has been greatly developed. The purpose of this paper is to review the application and development of cell apoptosis imaging with radionuclide tracing techinique.
作者 王荣福
出处 《国际放射医学核医学杂志》 2007年第4期201-204,共4页 International Journal of Radiation Medicine and Nuclear Medicine
基金 高校博士点学科专项科研基金项目(20050001108) 教育部教育振兴行动计划特殊专项(“九八五”工程:II期)资助项目(985-2-056) 国家重点基础研究发展计划(973计划)资助项目(2006CB705705)
关键词 细胞凋亡 放射性核素显像 钙磷脂结合蛋白 Apoptosis Radionuclide imaging Annexin V
分类号 Q [生物学]
  • 相关文献

参考文献22

  • 1Saikumar P, Dong Z, Mikhailov V, et al. Apoptosis: definition, mechanisms, and relevance to disease. Am J Med, 1999, 107 (5): 489-506.
  • 2Wang RF, Liu M, Zhang CL, et al. Study on mice tumor-bearing cell apoptosis imaging in vivo after a single dose of chemotherapy. J Nucl Med, 2006, 47( 5 suppl 2): 416P.
  • 3王荣福,刘萌.放射性AnnexinⅤ活体细胞凋亡显像在肿瘤研究中的应用及进展[J].中国医学影像技术,2004,20(10):1616-1619. 被引量:11
  • 4Narula J, Strauss HW. Implications of phosphatidylserine (PS) reversal in acute ischemic syndromes. J Nucl Med, 2003, 44 (3): 397-399.
  • 5BrauerM. In vivo monitoring of apoptosis, Prog Neuro Psychopharmacol Biol Psychiatry, 2003, 27(2):323-331.
  • 6Boersma HH, Kietselaer BLJH, Stolk LML, et al. Past, present, and future of annexin A5: from protein discovery to clinical applications. J Nucl Med, 2005, 46(12): 2035-2050.
  • 7Iahorte C, van de Wiele C, Bacher K, et al. Biodistribution and dosimetry study of 123I-rh-Annexin V in mice and humans. Nucl Med Commun, 2003, 24(8): 871-880.
  • 8兰晓莉,张永学,安锐,高再荣,曹国祥.~99TC^m-HYNIC-Annexin V的制备及其在健康小鼠体内的分布[J].中华核医学杂志,2005,25(6):344-346. 被引量:9
  • 9Murakami Y, Takamatsu H, Taki J, et al. ^18F-labelled annexin V: a PET tracer for apoptosis imaging. Eur J Nucl Med Mol Imaging, 2004, 31 (4): 469-474.
  • 10Belhocine T, Steinmetz N, Green A, et al. In vivo imaging of chemotherapy-induced apoptosis in human cancers. Ann N Y Acad Sci, 2003, 10(10): 525-529.

二级参考文献43

  • 1黄建敏,潘莉萍,李冬雪,吴炜杰,李会春.^(99)Tc-MDP治疗强直性脊柱炎的疗效观察[J].中华核医学杂志,2005,25(3):174-175. 被引量:22
  • 2陈跃,黄占文,何菱,郑时龙,李举联,秦大莲.^(99)Tc^m-DTPA-DG的制备及其荷瘤裸鼠实验研究[J].中华核医学杂志,2005,25(3):176-178. 被引量:28
  • 3Takei T,Kuge Y,Zhao S,et al.Time course of apoptotic tumor response after a single dose of chemotherapy:comparison with 99TcmAnnexin V uptake and histologic findings in an experimental model.JNucl Med,2004,45:2083-2087.
  • 4Kartachova M,Haas RL,Olmos RA,et al.In vivo imaging of apoptosis by ^99Tc^m-Annexin V scintigraphy:visual analysis in relation to treatment response.Radiother Oncol,2004,72:333-339.
  • 5Kemerink GJ,Liem IH,Hofstra L,et al.Patient dosimetry of intravenously administered ^99Tc^m-Annexin V.J Nucl Med,2001,42:382-387.
  • 6Kemerink GJ,Boersma HH,Thimister PWL,et al.Biodistribution and dosimetry of ^99Tc^m-BTAP-Annexin V in humans.Eur J Nucl Med Mol Imaging,2001,28:1373-1378.
  • 7Purohit A,Liu S,Casebier D,et al.Phosphine-containing HYNICderivatives as potential bifunctional chelators for ^99Tc^m labeling of small biomolecules.Bioconjug Chem,2003,14:720-727.
  • 8Verbeke K,Kieffer D,Vanderheyden JL,et al.Optimization of the preparation of ^99Tc^m labeled HYNIC-derivatized Annexin V for human use.Nucl Med Biol,2003,30:771-778.
  • 9Blankenberg FG,Katsikis PD,Tait JF,et al.Imaging of apoptosis(programmed cell death)with ^99Tc^m-Annexin V.J Nucl Med,1999,40:184-191.
  • 10Kemerink GJ,Liu X,Kieffer D,et al.Safety,biodistribution,and dosimetry of ^99Tc^m-HYNIC-Annexin V,a novel human recombinant Annexin V for human application.J Nucl Med,2003,44:947-952.

共引文献40

同被引文献142

引证文献8

二级引证文献57

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部