小剂量^131I治疗青少年Graves’病85例患者疗效观察

The observation of curative effects by therapy with low-dose ^131I in younger with Graves＇ disease

目的探讨小剂量^131I治疗青少年Graves，病的疗效。方法均采用^131I治疗，每克甲状腺组织给^131I为1480—2220kBq，并结合患者年龄、甲状腺质量、病程、是否曾用过抗甲状腺药物治疗等进行综合考虑确定^131I治疗剂量。参照对^131I治疗后疗效评价标准，将治疗结果分为完全缓解（包括甲状腺功能正常和甲状腺功能减退）、显效、部分缓解、无效。结果85例患者中，一次治疗完全缓解41例，显效34例，部分缓解10例，无效为0，总有效率为100％。结论小剂量^131I是治疗青少年Graves’病有效、简便、安全的方法，重复治疗可以提高Graves’病的治愈率，不会明显增加甲状腺功能减退的发生率。

Objective To observe the the curative effects in younger with Graves disease therapied by ^131I. Methods The dose of ^131I is administrated with 1480-2220kBq/g of thyroid tissue which was decided by many factors that include the paticnt＇s Age, volume of thyroid, course and if antihyroid drug is administrated. The curative effects was classfide into four groups： complete remission, excellence, parts of remission, no effect. Results 47 were complete remission, 34 were excellence, 10 were the parts of remission and 0 was no effects. The total effective power was 100%. Conclusions Therapy with low-dose of ^131I for younger with Graves＇ disease is an effect, simple and safe method. Repeating treatment with ^131I will improve the curative rate of Graves ＇ disease in younger, and the incidence of hypothyroidism cannot be increased.