阻塞性睡眠呼吸暂停低通气综合征与记忆功能改变的关系

Relationship between Pathophysiological Changes and Memory Function in Patients with Obstructive Sleep Apnea/ Hypopnea Syndrome

目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者主要的病理生理改变及其与记忆功能变化的关系。方法对21例OSAHS患者用Epworth嗜睡量表评估白天过度瞌睡状态。用多导睡眠监测(PSG)检查睡眠有效率、呼吸暂停低通气指数、最低血氧饱和度、平均血氧饱和度和血氧饱和度低于90%的睡眠时间。应用神经心理测验量表对患者进行记忆功能检查。采用SPSS11.5软件对各指标进行逐步多元回归分析。结果OSAHS患者的记忆商与血氧饱和度<90%的睡眠总时间有显著相关性(其标准化的回归系数为-0.643,P<0.01);与睡眠有效率、呼吸暂停低通气指数、夜间最低血氧饱和度、夜间平均血氧饱和度及白天嗜睡程度无显著相关性。结论OSAHS患者的记忆功能变化是由夜间低氧血症所致。OSAHS患者的记忆功能与用睡眠呼吸暂停低通气指数和最低血氧饱和度2个指标判断的病情严重程度无关。

Objective To investigate the relationship between the pathophysiological changes and memory function in patients with obstructive sleep apnea/hypopnea syndrome（OSAHS）. Methods Twenty-one patients with OSAHS were monitored for sleep efficiency, apnea/hyponea index, minimal oxygen saturation（SaO2 ） during sleep, average oxygen saturation during sleep and total sleep time of SaO2 〈90% by polysomnography tests. Their memory functions were measured by neuropsychological tests. The Epworth sleepiness scale was used to assess the degree of patients＇ daytime somnolence. Results Memory function of patients with OSAHS was significantly associated with total sleep time of SaO2 〈 90% （standardized coefficients = -0.643, P 〈 0.01 ） ; but memory function of patients with OSAHS was not associated with sleep efficiency, apnea/hypopnea index（ AHI）, average oxygen saturation（SaO2 ） during sleep, minimal SaO2 during sleep and excessive daytime somnolence（EDS）. Conclusion Memory function in patient with OSAHS correlates with hypoxia. AHI and SaO2 are not sensitive for assessment of the memory dysfunction in those patients.