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CD147与基质金属蛋白酶-2,3,9在卵巢癌中的表达及临床病理意义 被引量：8

Expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance
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摘要 目的:检测CD147和基质金属蛋白酶(MMP)-2,3,9在卵巢癌中的表达,了解其与卵巢癌临床病理特征之间的关系,探讨卵巢癌中CD147与MMP-2、MMP-3和MMP-9表达的相关性。方法:用免疫组化SP法对40例卵巢癌组织,9例良性卵巢上皮性肿瘤组织中CD147和MMP-2、MMP-3、MMP-9的表达情况进行检测。结果:CD147和MMP-2、MMP-3及MMP-9在卵巢癌中的阳性表达率分别为92.5%,100%,100%和95%,阳性表达与病理分级和临床分期有关(P<0.05),与组织学类型无关,与临床预后无显著相关(P>0.05)。在卵巢癌中,CD147与MMP-2、MMP-3和MMP-9多同时表达,呈现出显著正相关,相关系数分别为0.802,0.786,0.914(P<0.001)。结论:卵巢癌组织中CD147、MMP-2、MMP-3及MMP-9的表达与的临床分期及病理分级有关。MMP-2、MMP-3和MMP-9的分泌增加可能与CD147的诱导促进作用有关系。 Objective：To investigate the expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance. Methods：Immunohisto chemical S-P method was performed to detect the expressions of MMP-2,MMP-3,MMP-9,CD147 in 40 malignant and 9 benign ovarian tumors. Result：The expression rates of MMP-2, MMP-3,MMP-9 and CD147 in ovarian cancer were 92.5%,100%,100% and 95%,respectively. The expressions of MMP-2, MMP-3,MMP-9 and CD147 in ovarian cancer were related with clinical stage and pathological garade （P〈0.05） but not with the histological type and clinical prognosis （P〉0.05）. There were positive correlations between the expressions of CD147 and MMP-2,MMP-3,MMP-9 （r=0.802,0.786,0.914）in ovarian cancer. Conclusion：Expressions of CD147,MMP-2,MMP-3 and MMP-9 have relevance to clinical stages and pathological grades in ovarian cancer,and overexpression of CD147 may induce the secretion of MMP-2,MMP-3,MMP-9.
作者 巫静娴 赵涌 贾世军 李圆圆
机构地区 重庆医科大学基础医学院病理学教研室
出处 《重庆医科大学学报》 CAS CSCD 2007年第11期1165-1168,1184,共5页 Journal of Chongqing Medical University
关键词 CD147 基质金属蛋白酶-2 基质金属蛋白酶-3 基质金属蛋白酶-9 卵巢癌 免疫组化 CD147 Matrix metalloproteinase-9 Matrix metalloproteinase-2 Matrix metalloproteinase-3 Ovarian cancer Immuno- histochemistry
分类号 R737.31 [医药卫生—肿瘤]
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参考文献13

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重庆医科大学学报
2007年 第11期

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