羟氯喹对类风湿关节炎患者血清淀粉样蛋白A水平影响的研究

Influence of hydroxychloroqulne upon serum amyloid protein A level of patients with rheumatoid arthritis

目的探讨羟氯喹（HCQ）对类风湿关节炎患者血清淀粉样蛋白A（SAA）水平的影响。方法用终点散射比浊法研究了30例类风湿关节炎患者HCQ（400mg/d）治疗前后血清SAA水平的变化。结果HCQ治疗4周后血清SAA水平明显降低，以后进一步降低（P〈0．05）。结论HCQ能有效地降低类风湿关节炎患者血清SAA水平，抑制类风湿关节炎活动，诱导病情缓解。

Objective To probe the influence of hydroxychloroquine （HCQ） upon serum amyloid protein A （SAA） level of patients with rheumatoid arthritis （RA）. Methods The change of the SAA level was studied by nephelometry immunoassay with Behring BN ProSpec system in 30 patients with RA before and after treatment of HCQ （400 mg/d）. Results After 4 weeks when they were treated with HCQ, the serum SAA level reduced notably, and then conlinously reduced（P 〈 0.05 ）. Conclusion HCQ can reduce the serum SAA level of the patients with RA, and make their conditions improve.