冠心病患者血浆NPY、β_2-m、CTnI和Ferritin水平的改变

Study on Changes of Plasma NPY,β_2-m,CTnI and Ferritin Levels in Patients with Coronary Heart Disease

目的:观察冠心病患者血浆中NPY、β2-m、CTnI和Ferritin水平的改变。方法:我们应用放射免疫分析和化学发光免疫分析测定了86例急性心肌梗死(AMI);145例不稳定型心绞病(UAP)、28例稳定型心绞痛(AP)和40例正常对照组血浆NPY、β2-m、CTnI和Ferritin的水平。结果:40例正常对照组血浆NPY、β2-m、CTnI和Ferritin分别为(151.31±22.82)pg/ml,(2.23±0.46)μg/ml、(0.011±0.006)ng/ml和(230.10±46.30)ng/m,除男性血浆Ferritin水平稍高于女性外,血浆NPY、β2-m、CTnI水平男女之间无差异。86例AMI血浆中NPY、β2-m、CTnI和Ferritin分别为(345.12±68.71)pg/ml、(6.31±1.94)μg/ml、(0.091±0.027)ng/ml和(694.2±205.8)ng/ml,明显高于40例正常对照组(P均<0.001);145例UAP血浆中NPY、β2-m、CTnI和Ferritin分别为(225.61±40.7)pg/ml、(4.85±1.55)μg/ml、(0.059±0.013)ng/ml和(584.6±191.2)ng/ml,明显高于正常组(P均<0.01);而28例AP血浆CTnI和Ferritin分别为(0.031±0.014)ng/ml和(387.1±168.6)ng/ml,也明显高于正常对照组(P分别<0.05,<0.05)。结论:冠心病患者血浆NPY、β2-m、CTnI和Ferritin的水平是衡量心肌细胞损伤的重要标志物,并且与病情的进展有较为密切关系,可作为诊断和治疗的指标。

Objective To study the changes of plasma NPY, β2 - m, CTnI and ferritin levels in patients with coronary heart disease. Methods Plasma NPY, β2 -m （with RIA） CTnI and ferritin （with CLIA） levels in 86 patients with AMI, 145 patients with UAP, 28 patients with AP and 40 cortrols. Results The plasma levels of NPY, β2 -m, CTnI and ferritin in 40 controls were 151. 31 ± 22.82pg/ml, 2.23 ± 0.45μg/ml, 0.011 ± 0. 006ng/ml and 230. 10 ± 46.30ng/ml respectively, with no significant differences related to sex （ P 〉 0.05 ）, The plasma levels of NPY, β2 - m, CTnI and ferritin in 86 patients with AMI, 145 patients with UAP and 28 patients with AP（ except plasma NPY and plasma β2 - m） were all significantly higher than those in controls （P 〈 0.05 ）. Concluion Plasma NPY, β2 - m, CTnI and ferritin are important and clinically useful markers of myocardial isehemic injury and their levels are well - correlated with the severity of the disease process.