慢性肾病患者血清SIL-2R、TNF-α和血浆VEGF检测的临床意义

Clinical Significance of Determination of Changes of Serum Soluble Interleukin-2 Receptor (SIL-2R),Tumor Necrosis Factor﹣α (TNF-α) and Plasma Vascular Endothelial Growth Factor (VEGF) Levels After Treatment in Patients with Chronic Nephropathy

目的:探讨慢性肾病患者血清SIL-2R、TNF-α和血浆VEGF水平的变化及意义。方法:应用放免法和酶联双抗体法对32例慢性肾病患者进行了血清SIL-2R、TNF-α和血浆VEGF水平测定,并与35名正常健康人作比较。结果:慢性肾病患者血清SIL-2R、TNF-α和血浆VEGF水平显著地高于正常人组(P<0.01),经治疗6个月后与正常人比较仍有差异(P<0.05)。结论:慢性肾病的发生、发展与SIL-2R、TNF-α和VEGF水平密切相关。

Objective To investigate the changes of serum SIL - 2R, TNF -α and plasma VEGF levels after treatment in patients with chronic nephropathy. Methods Serum TNF -α levels were determined with RIA and serum SIL - 2R, plasma VEGF levels with ELISA in 32 patients with chronic nephropathy both before and after treatment as well as in 35 controls. Results Before treatment, the serum SIL - 2R, TNF -α and plasma VEGF levels were significantly higher in the patients than those in the controls （P 〈 0.01 ）. After 6 months of treatment, the levels though dropped markedly, remained significantly higher （ P 〈 0.05）. Conclusion Development of chronic nephropathy was closely related to the serum SIL - 2R, TNF -α and plasma VEGF levels.