2005年新疆77株伤寒沙门菌对抗菌药物的耐药性监测分析

Surveillance and Analysis of Resistance to Antibacterials of 77 Strains of Salmonella typhi in Xinjiang in 2005

目的了解伤寒沙门菌对抗菌药物的耐药性。方法收集伤寒发病地区的菌株,按肠道菌常规方法鉴定,采用琼脂扩散法(K-B法)进行耐药性测定。结果77株菌对卡那霉素、多粘菌素B、庆大霉素、丁胺卡那霉素、氟哌酸、菌必治、奥氟星、环丙沙星、复达星敏感率均为100%,红霉素耐药率最高(97.40%)。仅有2株对21种抗菌药物全部敏感,其余75株菌均有不同程度耐受;3个县伤寒沙门菌抗生素耐受情况不同。结论新疆是伤寒病的高发区,抗生素耐受情况仍很严重,因此在伤寒防治实践中科学、合理的使用抗菌药物。

Objective In order to get the message of resistance to antibacerials of Salmonella typhi. Methods Strains of Salmonella typhis collected in epidemic areass were identified with routine method and their resistance was determined by Agar. Results Of the 77 tested strains, 100% were susceptible to Kanamycin, Polymyxin B , Gentamycin , Amikacin , Norfloxacin , Ceftriaxone , Ofloxacin , Cefrofloxacin, Ceftazidime , with the highest resistant rate of 97.40% to erythromycin. There were only two strains being sensitive to all 21 antibacerials , and the other 75 strains were of tolerance to some degrees. The resistance was different among Jiashis Bachu and Yopurga County of Kaxgar Prefecture. Conclusions Xinjiang is a highly prevalent area of typhoid fevers with severe resistance to antimicrobialss so the scientific and appropriate use of antimicrobial agents is still very vital.