茯茶毒理学试验报告

Study on the Toxicity Experiments of Fuzhuan Tea

以提制的速溶茯茶为原料，采用药物毒理学试验方法，研究了速溶茯茶对小鼠与大鼠的毒理特性。结果表明，茯茶对雄性小鼠的急性经口LD50为14700mg／kg·bw，对雌性小鼠的急性经口LD50为19600mg／kg·bw（95％可信限为10600-36000），Ames及致小鼠精子畸形试验均为阴性。以含0．85％、1．25％、1．70％速溶茯茶的饲料喂饲大鼠30d，各组大鼠生长发育良好，各剂量组对雌雄鼠血像、雄鼠血生化各项、甘油三酯、尿素酐、血肌酐、血糖和雌雄鼠脾，体、肾，体比值、组织病理均无显著影响（P〈0．05），表明茯茶实际属无毒物。

The toxic experiment of Fuzhuan tea was carried out by using the extracted instant Fuzhuan tea as material in order to evaluate its safety for the mice and rat. The results showed that the LD50 of male mice and female mice was 14700 mg/kg·bw and 19600 mg/kg·bw respectively（the limit reliability was 10600-36000）, and both of the Ames test and the semen teratogenicity results were negative. During the 30 days fed by the feeding mixed with 0.85%, 1.25%, 1.70% instant Fuzhuan Tea for the rat rats of each dose group grew well, the hemogram indexes of rats from each dosage, blood biochemical indexes and triglyceride, Urea anhydride, blood muscle anhydride and blood sugar indexes, ratio of spleen to body weight, kidney to body weight, and the histopathological characteristic of all test rats showed no significantly difference （P〈0.05）, which suggested Fuzhuan Tea was a no poisonous food.