特异性肌松拮抗药Sugammadex研究进展

Development of Sugammadex——A Selective Relaxant Binding Agent

Sugammadex是一种新型的特异性甾体类非去极化肌松药掊抗药，它并不作用于胆碱脂酶，主要直接和氨基甾体类肌松药结合，通过其独特的化学螯合作用，可快速，安全、有效，并呈剂量相关性逆转由罗库溴铵等甾体类肌松药所导致的神经肌肉阻滞作用，开创了一种全新的肌松拮抗机制。

Sugammadex is the name of a modified cyclodextrin. With its unique lipophilic and hydrophilic properties, it binds and inactivates aminosteroid nondepolarizing muscle relaxants, holding promise for a new concept in muscle relaxant reversal. Encapsulation rather than competitive antaganism of neuromuscular blockade. And it may be a future modality of anesthetic practice.