卡介菌多糖核酸联合5-氟脲嘧啶治疗扁平疣的临床观察

An Clinical Obervation of Verruca Plana Treated with BCG Polysaccharide Nucleic Acid Injection and 5-fluorouracil

目的:观察卡介菌多糖核酸注射液联合外用5-氟脲嘧啶治疗扁平疣的疗效。方法:选择2004年3月至2005年6月在荆楚理工学院附属医院就诊的89例扁平疣患者,随机分为2组:治疗组45例,应用肌肉注射卡介菌多糖核酸注射液联合外用5-氟脲嘧啶治疗;对照组44例,应用肌肉注射聚肌胞治疗,4个月后评定疗效。结果:治疗组总有效率91.11%,显著优于对照组(P<0.01);观察期间未见严重不良反应。结论:肌肉注射卡介菌多糖核酸注射液联合外用5-氟脲嘧啶治疗扁平疣安全有效。

Objective ：To investigate the effectiveness of BCG Polysaccharide Nucleic Acid （BCG -PSN） Injection and 5 - fluorouracil in patients with Verruca plana. Methods：89 patients with Verruca plana from March,2004 to June,2005 were randomly divided into two groups：treatment group （45 cases with Verruca plana were treated with BCG - PSN Injection and 5 - fluorouracil） and control group （44 cases with Verruca plana were treated with polyinosinic - polyoytidylic acid）. The therapeutic response was evaluated 4 months later. Results：The rate of effectiveness in the treatment group was 91.11% and was higher than that in the control group significantly（ P 〈 0.01 ）. In the observation period, severe side effects were not found. Conclusion： BCG - PSN Injection and 5 - fluorouracil is effective and safe in treatment of Verruca plana.