摘要
目的探讨奎硫平对治疗难治性精神分裂症的疗效及安全性。方法将98例难治性精神分裂症患者随机分为实验组和对照组,分别给予奎硫平、氯氮平治疗8周,用阳性与阴性症状量表评价临床疗效,用不良反应量表评价药物副反应。结果奎硫平治疗有效率为44.9%,氯氮平治疗有效率48.9%,两组之间差异无显著性(P>0.05);奎硫平在嗜睡、口干、便秘、流涎、体重增加、心动过速、心电图异常、恶心呕吐、白细胞减少等方面显著少于氯氮平。结论奎硫平是治疗难治性精神分裂症安全、有效的药物。
Objective To investigate the curative effect and safety of quetiapine in refractory schizophrenia. Methods 98 patients with refractory schizophrenia were randomly divided into experimental group and control group, respectively treated with quetiapine or clozapine for 8 weeks. The curative effect and side-effect were evaluated with PANSS and TESS. Results The effective rates of quetiapine and clozapine were respectively 44.1% and 52.9%, there was no significant difference between them（P〉 0.05 ）. But the side-effects of quetiapine such as somnolence, dry mouth, constipation, hypersalivation, weight gain, tachycardia, abnormal ECG, nausea and leucopenia decreased significantly. Conclusion Ouetianine was a safe and effective drug in treating refratory schizophrenia.
出处
《中国现代医生》
2007年第10X期24-25,共2页
China Modern Doctor
