血管紧张素转换酶基因插入/缺失多态性与维吾尔族人群高血压病的关系

Association Study on Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme Gene with Essential Hypertension in Xinjiang Uyigur Group

目的探讨血管紧张素转换酶基因的插入/缺失多态性与新疆维吾尔族人群高血压病之间的关系。方法应用聚合酶链反应对361例维吾尔族高血压病患者和400例正常血压者的血管紧张素转换酶基因16内含子插入/缺失多态性进行检测,测定血清总胆固醇、甘油三酯、血糖和总胆红素等生物化学指标,Logistic回归分析各基因型和等位基因频率与新疆维吾尔族原发性高血压的关系。结果将维吾尔族人群用Logistic回归模型校正年龄、性别、肥胖指数、腰围、臀围、盐摄入量、血糖、甘油三酯及总胆固醇之后,血管紧张素转换酶基因插入/缺失多态性与高血压病的发生相关,偏回归系数β值为0.246(P=0.0302),携带突变型纯合子DD个体患高血压的风险为II基因型的1.51倍(P=0.038)。结论血管紧张素转换酶基因插入/缺失多态性与新疆维吾尔族人群高血压发病相关,DD基因型可能是维吾尔族人群高血压发病的风险因子。

Aim To investigate whether the insertion/deletion（I/D） polymorphism in the angiotensin converting enzyme（ACE） gene is associated with essential hypertension in Xinjiang Uyigur isolated population.Methods The study covered 361 hypertension patients and 400 normotensive controls,the variant of ACE I/D was determined by polymorphism chain reaction（PCR）.Some biochemical index such as serum total cholesterol（TC）,triglyceride（TG）,glucose（GLU） and total bilirubin（TBIL） were also measured.Results Using logistic regression analysis,adjusted for age,sex,body mass index（BMI）,waist circumference,hip circumference,intake of salt,GLU,TC,TG,there was a relationship between hypertension and ACE gene I/D polymorphism,and the parameter β is 0.246（P=0.0302）.The odds ratio for hypertension of DD versus II homozygote individuals was 1.51（P=0.038）.Conclusions The results suggest that the I/D polymorphism of ACE gene is associated with the hypertension in the Uyigur population of Xinjiang.And the DD genetype may be the risk factor of hypertension.