急性阿片处理对学习记忆功能的影响

Effect of acute opioid treatment on learning and memory

阿片长期处理能够造成动物对阿片产生顽固性的病理性记忆,表明学习记忆参与了阿片依赖过程。阿片本身对动物的学习记忆过程也能产生明显的影响。基于不同的研究模型和不同的给药方案,阿片可能分别对记忆形成、巩固和再现过程表现出抑制或促进作用,其作用的复杂性反映了阿片受体及其与多种非阿片受体间相互作用的多样性。尽管目前仍有争论,但有关这方面的研究已经取得了较大进展。

Refractory pathological memory on opioid will be generated in animals after chronic opioid treatment, which revealed the participation of learning and memory in opioid dependence. Opioid also exhibits significant influence on learning and memory itself. Based on different animal models and different programs for drug treatment, opioid produces inhibition or enhancement on memory formation, consolidation and retrieval, respectively. The complexity of the effect of opioid on memory reflects the variety of interaction between opioid receptors and many non-opioid receptors. In spite of all the controversy, great progress has been made in this field in recent years.