PPARδ激动剂研究进展

Research progress in PPARδ agonists

过氧化物酶体增殖物活化受体δ(PPARδ)是一个由配体激活的核转录因子,属于核激素受体(nuclear hormone receptor)超家族。PPARδ被激活后,能增加逆向胆固醇转运,调节脂质和糖类代谢。因此,PPARδ激动剂有可能成为肥胖、糖尿病、代谢综合征以及动脉粥样硬化等心血管疾病的有效治疗药物。本文对现有的天然及合成PPARδ激动剂进行综述。

Peroxisome proliferator-activated receptor δ （PPARδ） is a ligand-activated nuclear transcription factor, belonging to nuclear hormone receptor superfamily. Activated by agonists, PPARδ can increase reverse cholesterol transport, and modulate lipid and glucose metabolism. Therefore, PPARδ agonists are promising drugs for the treatment of obesity, diabetes, metabolic syndrome and atherosclerosis. In this article, the development of natural and synthetic PPARδ agonists is reviewed.