老年男性血清睾酮与代谢综合征的关系

Association of serum testosterone with metabolic syndrome in aged men

目的探讨老年男性中血清睾酮与代谢综合征的关系。方法研究对象为48例老年男性,测定身高、体重、体质指数、腰围、血糖、血胰岛素、血脂,用放射免疫法测定血清睾酮浓度,并用稳态公式(HOMA)计算胰岛素抵抗(HOMA-IR),采用2001年美国国家胆固醇教育计划成人治疗小组(NCEP-ATPⅢ)提出的诊断标准进行分组,分析血清睾酮与代谢综合征的关系。结果在老年男性中,有代谢综合征者睾酮浓度水平低于无代谢综合征者(P<0.05),通过调整年龄、吸烟、饮酒、体力活动后,睾酮浓度与代谢综合征发生显著负相关(P<0.01)。结论老年男性血清睾酮浓度与代谢综合征的发生密切相关,低睾酮水平是代谢综合征发生的重要参考标志之一。

Objective To study the association of sermn testosterone （T） with metabolic syndrome （MS） in aged men. Methods A total of 48 aged male participants were included in this study. MS criteria were defined by modified NCEPATPIII. Height, weight, body mass index （BMI）. abdominal girth, blood pressure, fasting lipid, fasting blood glucose, blood insulin and HOMA-IR were measured in all participants. Serum testosterone concentration was measured by radioimmunological method. Results Serum T concentration was significantly lower in aged men with MS than that in patients without MS （P〈0.05）. After adjusting the influences of age, smoking, alcohol consumption and physical activity, a significant association was elicited between scrim T and occurrence of MS （P〈0.05）. Conclusions The results indicated that serum level was closely associated ith the occurrence of MS and a lower concentration of serum T may be a valuable marker of MS.