系统性红斑狼疮患者外周血T淋巴细胞亚群的变化

The Change of Peripheral Blood T Lymphocyte Subsets in Patients with Different Clinical Types of Systemic Lupus Erythematosus

目的:研究系统性红斑狼疮(SLE)患者外周血T淋巴细胞亚群变化及其临床意义。方法:对30例患者和20例健康者,采用特异性荧光抗体标记,流式细胞检测T淋巴细胞亚群的变化。结果:SLE活动组CD4+细胞数明显降低(P<0.05);CD4+/CD8+比值明显降低(P<0.05)。结论:T淋巴细胞亚群在SLE的发病机制中起重要作用。

Objective To study the change of T lymhocyte subsets with systemic lupus erythematosus. Methods 30 patients with systemic lupus erythematosus and 20 cases of healthy subjects were investigated and the change of T Lymphocyte subsets were counted by flow cytometer. Results Decrease in CD4^＋ cells and was observed in SLE patients（P 〈 0.05 ）, Conclusion T lymphocyte isplay an important role in the development of SLE.