原发性肝癌与乙型肝炎病毒以及甲胎蛋白的关系

Relationship between primary hepatic carcinoma and hepatitis B virus and alpha fetoprotein

目的：探讨乙肝病毒和甲胎蛋白（AFP）对原发性肝癌（PHC）患者的检测意义,从而提高PHC的早期诊断水平。方法：采用ELISA方法,对96例PHC患者的甲胎蛋白水平进行检测。结果：96例PHC患者中,HBsAg阳性80例（86.45%）、HBeAg阳性25例（26.04%）、HBeAb阳性54例（56.25%）、HBcAb阳性80例（83.33%）、HBV-DNA阳性76例（78.54%）、HBVm均阴性13例（13.54%）。96例PHC患者中,有乙肝病史者40例（41.67%）、有肝硬化病史者32例（33.33%）、乙肝病毒携带者24例（25.0%）,有83例与乙肝有关、5例为丙肝患者、未查出病原学的患者8例。96例PHC患者中,AFP〉400ng/mL者52例（54.16%）、20-400ng/mL者33例（34.37%）、〈20ng/mL者11例（11.46%）。结论：大多数患者PHC的发生与HBV感染所致的慢性乙型肝炎和肝硬化密切相关。

Objective,To investigate the detection of hepatitis B virus （HBV） and alpha fetoprotein （AFP） to improve the early diagnosis of primary hepatic carcinoma （PHC）. Methods ：AFP was detected by methods of ELISA in total 96 cases of PHC, Results.The positive rates of HBsAg, HbeAg ,HBeAb,HbcAg and HBV-DNA were 80 cases （86.45%）,25 cases（26.04%）,54 cases（56.25%）,80 cases（83.33%） and 76 cases （78.54%） ,respectively. 13 cases showed the negative rates of HBVm（13.54%）. In total 96 cases, 40 cases （41.67 %） were chronic hepatitis B, 32 （33.33%） were liver cirrhosis, 24 （25%） were hepatitis B virus carrier,83 were correlated with hepatitis B, 5 were hepatitis C, and 8 were anetiological. In total 96 cases of PHC,AFP was more than 400ng/mL in 52 cases （54. 16%）, AFP between 20ng/mL and 400ng/ mL in 33 cases （34. 37%） and AFP lower than 20ng/mL in 11 cases （11.46%）. Conclusion：Most of the PHC cases are closely correlated with chronic hepatitis B and liver cirrhosis caused by HBV infection.