胰岛素泵及常规胰岛素治疗早期糖尿病肾病的对比研究

Study on comparison of insulin pump and regular insulin in the treatment of early diabetic nephropathy

目的:观察胰岛素泵治疗(CSII)与常规胰岛素治疗(MSII)对早期糖尿病肾病(DN)患者的疗效差异。方法:分别用胰岛素泵治疗(CSⅡ)和常规胰岛素治疗(MSⅡ)方法对40例和46例同期住院的早期糖尿病肾病患者进行了治疗。结果:CSII治疗组和MSII治疗组糖尿病肾病患者治疗后尿微量白蛋白排泄率(UAER)均明显下降。β2微球蛋白(β2M)也下降;但CSII组糖尿病肾病患者较MSII组下降更为明显。结论:胰岛素治疗能降低早期糖尿病肾病患者尿微量白蛋白及β2微球蛋白,而胰岛素泵治疗效果更理想。

Objective：To compare the different effect between continuous subcutaneous insulin injection （CSII） and multiple subcutaneous insulin injection（MSII） on diabetic nephropathy. Methods ：40 cases of early diabetic nephropathy with CSII and 46 cases with MSII were treated in the same period of time. Results： the urinary albumin excretion rate （UAER） of both CSII and MSII group were significantly decreased after treatment, and the β-2 microglobulin （β-2M） were decreased as well. but the UAER and β-2M in CSII group had a more remarkable decrease than that in MSII group. Conclusion：Insulin injection could decrease the urine microalbumine and β-2M of early diabetic nephropathy, and CSII could get a more effective treatment.