参附注射液对体外循环下冠状动脉搭桥术患者心肌的保护作用

Effect of Shenfu injection on cardiac protection in patients undergoing coronary artery grafting under cardio-pulmonary bypass

目的:探讨参附注射液对体外循环下行冠状动脉搭桥术患者的心肌保护作用。方法:选择体外循环下行冠状动脉搭桥术患者80例,随机分为2组各40例,参附组麻醉前30 min静脉滴注参附注射液1 ml/kg,对照组输入等量生理盐水.观察术中血流动力学变化,术中血管活性药物的使用、术后患者血清肌钙蛋白I(cTnI)、肌酸激酶同功酶(CK-MB)水平的变化情况。结果:参附组术中平均动脉压高于对照组,心率、中心静脉压低于对照组(P<0.05)。参附组术中多巴胺和硝酸甘油用量之比(DA/NTG)低于对照组(P<0.05),术后CK-MB、cTnI、LDH低于对照组(P<0.05)。结论:参附注射液对体外循环冠状动脉搭桥术患者的心功能有一定保护作用。

Objective：To investigate the influencee of Shenfu injection on cardiac protection in patients undergoing coronary artery grafting under cardio-pulmonary bypass. Methods： 80 patients were randomly divided into Shenfu group and control group. The Shenfu group was treated with 1 ml/kg Shenfu injection by intravenous infusion 30 min before anesthesia, and the control group was infused with 1 ml/kg saline. The following indices were observed during surgery： 1. hemodynamic changes; 2. dose of vaso-active drugs use; 3. CK-MB,cTnI,LDH and DA/NTG. Results： MAP was higher and HR,CVP were lower in Shenfu injection group（ P 〈 0.05 ） ; the dose of dopamine, nitroglycerin were less in Shenfu injection group（ P 〈 0.05 ） ; The levels of myocardial enzyme spectrum and cTnⅠ were much lower in Shenfu group than those in the control group （P 〈 0. 05 ）. Conclusion： Shenfu injection could protect cardiac function in the patients undergoing coronary artery bypass grafting.