天冬氨酸-β-环糊精在毛细管电泳中拆分手性药物罗格列酮

chiral separation of rosiglitazone in capillary electrophoresis using aspartate-β-cydodextrin

本文建立了一种快速、简单拆分手性药物"罗格列酮"的新方法。采用本实验室合成的天冬氨酸-β-环糊精为手性选择剂,在毛细管区带电泳中对罗格列酮进行拆分,通过优化影响实验的主要因素(手性选择剂浓度、缓冲溶液pH、柱温及分离电压),得到了使罗格列酮达到基线分离的最佳实验条件。

In this paper, a quick and simple method was developed for enantiomeric separation of rosiglitazone （Ros）. Using synthesized aspartate - β - cyclodextrin（ asp - β - CD） as chiral selector, ros was separated by capillary zone electrophoresis （CZE）. The best experimental conditions was obtained by optimazing the main experimental factors（asp- β -CD concentration, background buffer pH, the column temperature and applied voltage）.