摘要
本文建立了一种快速、简单拆分手性药物"罗格列酮"的新方法。采用本实验室合成的天冬氨酸-β-环糊精为手性选择剂,在毛细管区带电泳中对罗格列酮进行拆分,通过优化影响实验的主要因素(手性选择剂浓度、缓冲溶液pH、柱温及分离电压),得到了使罗格列酮达到基线分离的最佳实验条件。
In this paper, a quick and simple method was developed for enantiomeric separation of rosiglitazone (Ros). Using synthesized aspartate - β - cyclodextrin( asp - β - CD) as chiral selector, ros was separated by capillary zone electrophoresis (CZE). The best experimental conditions was obtained by optimazing the main experimental factors(asp- β -CD concentration, background buffer pH, the column temperature and applied voltage).
出处
《化学工程师》
CAS
2007年第10期55-56,59,共3页
Chemical Engineer
关键词
天冬氨酸-β-环糊精
罗格列酮
毛细管电泳
手性拆分
aspartate - β - cyclodextrin
capillary electrophoresis
rosiglitazone
chiral separation