焦虑症患者的条件负变化实验研究

Study on contingent negative variation in anxiety disorder

目的采用关联性负变(CNV)简化分析法验证CNV在焦虑症中的临床价值。方法运用改进的CNV分析法——早成分M1和晚成分M2技术,应用脑电生理仪检测39例焦虑症患者(焦虑症组)和35名正常人(正常对照组)的CNV。结果焦虑症组患者CNV波形不规则;其M1和M2潜伏期与正常对照组比较无统计学差异(P>0.05),但反应时间明显延迟,为(305±109)msvs(212±70)ms(P<0.01);焦虑症组CNV的M1和M2波幅均较正常对照组显著降低,分别为(6±3)μVvs(14±6)μV(P<0.01)和(11±5)μVvs(17±7)μV(P<0.05)。结论焦虑症患者存在注意障碍,其CNV变化值得进一步随访。

Objective To assess the clinical value of contingent negative variation （CNV） simplified analytic method in anxiety disorder. Methods CNV was recorded from 39 patients with anxiety disorder and 35 normal controls with American Brova instrument by modified CNV analytic method, early component M1 and late component M2 technique. Results Compared with normal controls, patients with anxiety disorder showed irregular CNV wave, similar M1 and M2 latency （ P 〉 0.05） and significantly delayed reaction time, （305 ±109）ms vs （212 ±70）ms （P 〈 0.01 ）. The M1 and M2 wave amplitude of CNV in patients with anxiety disorder were significantly lower than the normal controls, （6 ±3） μV vs （ 14 ±6） μV（P 〈0.01 ） and （ 11 ±5） μV vs （ 17 ±7 ） μV（ P 〈0.05）, respectively. Conclusion There exists disturbance of attention in patients with anxiety disorder, and the characteristics of CNV deserve further studying.