Ⅲ型胶原及β_2-MG测定对高血压肾损害诊断的意义

SIGNIFICANCE OF DETECTION OF SERUM/URINE LEVELS OF COLLAGEN Ⅲ AND MICROGLOBULIN β_2 IN THE DIAGNOSIS OF HYPERTENSIVE RENAL LESION

目的通过分析高血压病人血清、尿Ⅲ型胶原水平与β2-微球蛋白排泄率之间的关系，探讨血、尿Ⅲ型胶原及β2-微球蛋白排泄率测定对高血压肾损害诊断意义。方法用放射免疫分析测定57例高血压病人（高血压组）和57例健康对照者（对照组）血清、尿Ⅲ型胶原水平及尿β2-微球蛋白排泄率并进行比较。结果高血压组血清、尿Ⅲ型胶原及尿β2-微球蛋白排泄率均显著高于对照组，差异有显著性（t=3．78～10．53，P〈0．001）。高血压组血清、尿Ⅲ型胶原水平与尿β2-微球蛋白排泄率均呈显著正相关（r=0．31、0．32，P〈0．05）。结论血清、尿Ⅲ型胶原与尿β2-微球蛋白排泄率联合检测可能更有助于高血压性肾损害的早期诊断。

Objective Investigating the relationship between serum and urine levels of collagen Ⅲ （C-Ⅲ） and the excretion rate of urine β2 microglobulin （β2-MG） in order to evaluate their diagnostic value for renal damage in hypertensive patients. Methods Levels of serum and urine C-Ⅲ as well as the excretion rate of urine β2-MG were detected by radioimmunoassay in 57 patients and 57 healthy adults. Results Serum and urine C-Ⅲand excretion of urine β2-MG were significantly higher in the patients than those in the healthy adults （t=3.78-10.53,P〈0,001）. Positive correlation between the excretion of urineβ2-MG and serum and urine levels of C-Ⅲ was noticed in the patients （r=0. 31,0.32 ;P〈0.05）, Conclusion Combined detection of serum and urine levels of C-Ⅲ and excretion of urine β2-MG is in favor of early diagnosis of the disease.