摘要
目的通过分析高血压病人血清、尿Ⅲ型胶原水平与β2-微球蛋白排泄率之间的关系,探讨血、尿Ⅲ型胶原及β2-微球蛋白排泄率测定对高血压肾损害诊断意义。方法用放射免疫分析测定57例高血压病人(高血压组)和57例健康对照者(对照组)血清、尿Ⅲ型胶原水平及尿β2-微球蛋白排泄率并进行比较。结果高血压组血清、尿Ⅲ型胶原及尿β2-微球蛋白排泄率均显著高于对照组,差异有显著性(t=3.78~10.53,P〈0.001)。高血压组血清、尿Ⅲ型胶原水平与尿β2-微球蛋白排泄率均呈显著正相关(r=0.31、0.32,P〈0.05)。结论血清、尿Ⅲ型胶原与尿β2-微球蛋白排泄率联合检测可能更有助于高血压性肾损害的早期诊断。
Objective Investigating the relationship between serum and urine levels of collagen Ⅲ (C-Ⅲ) and the excretion rate of urine β2 microglobulin (β2-MG) in order to evaluate their diagnostic value for renal damage in hypertensive patients. Methods Levels of serum and urine C-Ⅲ as well as the excretion rate of urine β2-MG were detected by radioimmunoassay in 57 patients and 57 healthy adults. Results Serum and urine C-Ⅲand excretion of urine β2-MG were significantly higher in the patients than those in the healthy adults (t=3.78-10.53,P〈0,001). Positive correlation between the excretion of urineβ2-MG and serum and urine levels of C-Ⅲ was noticed in the patients (r=0. 31,0.32 ;P〈0.05), Conclusion Combined detection of serum and urine levels of C-Ⅲ and excretion of urine β2-MG is in favor of early diagnosis of the disease.
出处
《齐鲁医学杂志》
2007年第6期514-514,516,共2页
Medical Journal of Qilu
关键词
高血压肾损害
胶原Ⅲ型
Β2微球蛋白
hypertensive kidney lesion
collagen type Ⅲ
beta 2-microglobulin