肝窦内皮细胞与原发性移植肝功能不良

Endothelial Cell of Sinus Hepaticus and Primary Poor Graft Function

移植肝功能不良(PGF)是临床肝移植肝衰竭的常见原因。PGF的发生大多与缺血及其随后的再灌注损伤相关,肝血窦、特别是肝窦内皮细胞对缺血再灌注损伤比肝细胞更加敏感,内皮细胞引起的的微循环改变可能比肝实质细胞更能促使PGF的发生。本文对肝窦内皮细胞在其中的重要作用及减轻这一损伤的研究进展简要综述。

Poor graft function （PGF）is the common reason resulting in liver failure in clinical liver transplantation. Genesis of PGF is mostly related to ischemia and following reperfusion injury, Hepatic sinuseid, especially sinus endothelial cell is more sensitive to ischemic reperfusion injury than that of liver cells. Microcirculatory changes is more easy to promote the genesis of PGF that liver cells. So, this article reviews the importance of endothelial cells in hepatic sinus and study progresses on the question that how to relieve this injury.