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他汀类药物治疗慢性心力衰竭的研究 被引量：2

Study of Statins in Treatment for Chronic Heart Failure
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摘要 他汀类药物被广泛用于降低胆固醇,但近来的实验室及临床研究发现,他汀类药物用于慢性心力衰竭治疗,可延缓慢性心力衰竭进展,改善心功能,降低慢性心力衰竭病死率、致残率。本文就他汀类药物治疗慢性心力衰竭的临床证据、作用机制及目前存在问题等方面进行综述。 Statins has been widely used in decreasing cholesterol. But recent studies in laboratory and clinic showed that this drug can be used to treat chronic heart failure, which can prevent progress of chronic heart failure, improve hear function and decreasse case fatality and mutilation rate of chronic heart failure. This article reviews related clinical evidence, mechanism of action and suspending prebems at present of statins in treating chronic heart failure.
作者 赵春丽 黄其昌
机构地区 广西民族医院心内科
出处 《医学综述》 2007年第21期1655-1657,共3页 Medical Recapitulate
关键词 他汀类药物 慢性心力衰竭 治疗 Statins Chronic heart failure Treatment
分类号 R972 [医药卫生—药品] R541.61 [医药卫生—心血管疾病]
  • 相关文献

参考文献19

  • 1Ray T, GongY, Sykorak, et al. Statin use and survival outcomes in elderly patients with heart failure[ J]. Arch Intern Med, 2005,165 ( 1 ) : 62- 67.
  • 2Horwich TB, Maclellan WR, Fonarow GC. statin Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure[J] .J Am Coil Cardiol,2004,43(4):642-648.
  • 3李为民,韩薇.他汀类药物的应用及其安全性[A].胡大一,马长生主编.心脏病学实践2004-规范化治疗[M].北京:人民卫生出版社,2004.667-668.
  • 4赵水平.他汀类药物在慢性心力衰竭防治中的研究现状[J].中华老年心脑血管病杂志,2004,6(5):289-291. 被引量：15
  • 5Pliquett RW, Cornish KG, Peuler JD, et al. Simvastatin normalizes autonomic neural control in experimental heart failure [ J]. Circulation, 2003,107(6) :2493-2498.
  • 6Lou JD, Zhang WW, Zhang GP, et al. Simvastatin inhibits noradren alineinduced hypertrophy of cultured neonatal rat cardiomy ocytes[J]. Br J Pharmacol, 2001,104 (8) : 982-985.
  • 7Delbosc S, Cristol JP, Descomps B, et al. Simvastatin prevents angiotensinII induced cardiac alteration and oxidativestress [ J ]. Hypertension,2002,40(2) : 142-147.
  • 8Rosenson RS, Tangney CC, Casey LC, et al. Inhibition of proinflammatory cytokine production by pravastatin [ J ]. Lancet, 1999,353 (9157) : 983-984.
  • 9Cipollone F, Fazia M, Lezzi A, et al. Suppression of the functionallycoupled cyclooxygenase-2/pROStaglandinF, synthase as a basis of simv- astatin dependent plaque stabilization in humans[J]. Circulation,2003, 107(11) : 1479-1485.
  • 10尹芝兰,赵水平,周宏年.充血性心力衰竭患者血清细胞因子的变化及辛伐他汀的干预作用[J].中国现代医学杂志,2003,13(6):47-48. 被引量：63

二级参考文献17

  • 1Ray JG, Gong Y, Sykora K, et al. Statin use and survival outcomes in elderly patients with heart failure. Arch Intern Med,2005,165:62-67.
  • 2Chiu JH, Abdelhadi RH, Chung NK, et al. Effect of statin therapy on risk of ventricular arrhythmia among patients with coronary artery disease and an implantable cardioverter- defibrillator. Am J Cardiol, 2005,95:490-491.
  • 3Young XY, Jabbour S, Goldberg R, et al. Usefulness of statin drugs in protecting against atrial fibrillation in patients with coronary artery disease. Am J Cardiol,2003,92:1379-1383.
  • 4Okazaki S, Yokoyama T, Miyauchi K, et al. Early statin treatment in patients with acute coronary syndrome: demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH Study. Circulation,2004,110:1061-1068.
  • 5Salam AM. Intensive lipid-lowering therapy in coronary artery disease: implications of the REVERSAL and PROVE-IT trials. Expert Opin Investig Drugs,2004,13:707-713.
  • 6Mulukutla SR, Marroquin OC, Smith C, et al. Effect of statin therapy prior to elective percutaneous coronary intervention on frequency of periprocedural myocardial injury. Am J Cardiol, 2004, 94:1363-1366.
  • 7Karas RH. Statin use enhances coronary collaterals[J]. Am Heart J, 2003,146: 876-881.
  • 8Pliquett RU, Cornish KG, Peuler JD, et al. Simvastatin normalizes autonomic neural control in experimental heart failure [J]. Circulation, 2003,107: 2493-2498.
  • 9Grip O, Janciauskiene S, Lindgren S. Pravastatin down-regulates inflammatory mediators in human monocytes in vitro [J]. Eur J Pharmacol, 2000,410: 83-92.
  • 10Maack C, Kartes T, Kilter H, et al. Oxygen free radical release in human failing myocardium is associated with increased activity of racl-GTPase and represents a target for statin treatment[J]. Circulation, 2003,108: 1567-1574.

共引文献80

同被引文献30

  • 1蔡文阳,吴平彬,林育群,肖德明,林建华,陈海庆.辛伐他汀改善慢性心力衰竭预后的临床观察[J].中国实用内科杂志,2005,25(4):338-339. 被引量：14
  • 2赵水平.他汀类药物在慢性心力衰竭防治中的作用[J].中华心血管病杂志,2007,35(10):966-968. 被引量：27
  • 3Kar S, Ukil A, Das PK. Signaling events leading to the cu- rative effect of cystatin on experimental visceral leishma- niasis:involvement of ERK1/2,NF-kappaB and JAK/ STAT pathways [J]. Eur J Immunol, 2009,39 (3) : 741-751.
  • 4Zhang S,Zhang L,Sun A,et al. Efficacy of statin therapy in chronic systolic cardiac insufficiency:a meta-analysis [J]. Eur J Intern Med, 2011,22 (5) : 478-484.
  • 5Nakagomi A,Seino Y,Kohashi K,et al. Effects of statin therapy on the production of monocyte pro-inflammatory cytokines,cardiac function, and long -term prognosis in chronic heart failure patients with dyslipidemia [J]. Circ J,2012,76(9) :2130-2138.
  • 6Shunji H,Hiroyuki T,Tetsuya S,et al. Fluvastatin a 3- Hydroxy-3-methylglutaryl eoenzyme a reductase in- hibitor,attenuates left ventricuar remodeling and failure after experimental myocardial infarction [J]. Circulation, 2002,105(8) :868-873.
  • 7Fukuta H, Saned C, Brucks S,et al. Statin therapy may be associated with lower mortality in patients with dias- tolic heart failure:a preliminary report [J]. Circulation,2005, 112(3) :300-303.
  • 8汤玮,杨勇,刘惠亮.他汀类药物在慢性心力衰竭治疗中的研究进展[J].中华临床医师杂志:电子版,2012,16(20):6470-6472.
  • 9李拥军.正确认识他汀类药物在慢性心力衰竭治疗中的作用——关于CORONA研究的思考[J].临床荟萃,2008,23(5):305-306. 被引量：7
  • 10常宝成,于德民.他汀类药物的新评价[J].药品评价,2009,6(6):214-217. 被引量：5

引证文献2

二级引证文献19

医学综述
2007年 第21期

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