多棘蜈蚣化学成分的研究

Chemical analysis of Scolopendra multidens Newport

目的：分析多棘蜈蚣（ＳｃｏｌｏｐｅｎｄｒａｍｕｌｔｉｄｅｎｓＮｅｗｐｏｒｔ）的化学成分，并与药典收载品少棘蜈蚣（Ｓ．ｍｕｔｉｌａｎｓＬ．Ｋｏｃｈ）比较。方法：采用溶媒提取法测定总脂，气相色谱质谱计算机检测脂肪酸，微量凯氏定氮法测定蛋白质，离子交换色谱测定游离氨基酸，电感耦合离子发射光谱测定微量元素。结果：多棘蜈蚣含总脂７．２％，蛋白质６４．６％，游离氨基酸６．３％；含有与少棘蜈蚣相同的１５种脂肪酸（其中不饱和脂肪酸占７２％）、２１种氨基酸和１２种微量元素。结论：多棘蜈蚣与少棘蜈蚣主要化学成分类同，某些成分含量存在差异，是一种值得开发利用的药用蜈蚣资源。

OBJECTIVE: To analyse chemical composition of Scolopendra multidens Newport and compare it with S. mutilans L. Koch. METHODS: Lipid was determined by solvent extraction. GC MS DS system was used to analyse fat acids. The total protein was determined by the method provided by Chinese Pharmacopoeia (Appendix IX L.). Ion exchange chromatography was used for the analysis of free amino acids. ICP AES was used for the analysis of trace elements. RESULTS: The lipid content was 7.2%, protein was 64.6%, and total free amino acid was 6.3%. S. multidens contained the same fifteen fat acids (the content of unsaturated fat acids was nearly 72% in its fat acids), twenty one amino acids and twelve trace elements as S. mutilans had. CONCLUSION: S. multidens and S. mutilans have the same main chemcal composition. The contents of some compositions are different. S. multidens is worth exploiting as the nature resources of medicinal centepede.