大肠表面型病变组织学和P53、c-Myc表达

The histology of colorectal superficial lesions and expressions of P53 and c-Myc

目的研究人类大肠表面型病变的组织学特征及P53、c-Myc在大肠癌演变过程中的意义。方法采用免疫组化二步法,研究20例正常大肠黏膜、31例表面型病变、51例隆起型病变及31例大肠腺癌组织中P53、c-Myc的表达情况。结果大肠表面型病变的组织学均为腺瘤,且全部伴有不同程度的异型增生,与隆起型病变比较,两组中、重度异型增生的比例均有显著差异(P<0.05);大肠表面型病变的P53、c-Myc表达分别为3.2%及25.8%,其中P53表达与隆起型病变比较结果无差异(P>0.05),但c-Myc的表达两组有显著差异(P<0.05)。结论大肠表面型病变与大肠癌关系密切,P53、c-Myc在其向大肠癌演变过程中起重要作用。

Objective To study the histology characters of colorectal superficial lesions and the significance of P53 and c-Myc in colorectal cancer evolvement. Method Two-step immunohistochemistry was used to analyze the expression of P53 and c-Myc in 20 normal colorectal mucosa,31 superficial lesions,51 protruded lesions and 31 adenocarcinomas. Result All colorectal superficial lesions were adenomas with different grade dysplasia. Comparing with protruded lesions, the difference of moderate and severe dysplasia between the two kinds lesions had significant difference （P 〈 0.05）. The expression rates of P53 and c-Myc in colorectal superficial lesions were 3.2% and 25.8% , respectively. Comparing with protruded lesions, no significant difference was observed in P53 expression（P 〉 0.05）, but on the contrary to c-Myc（P 〈 0.05）. Conclusion Colorectal superficial lesions are highly correlated with colorectal cancer, P53 and c-Myc play important roles in colorectal cancer evolvement.