摘要
本文观察了10例正常人和14例库欣综合征患者垂体肾上腺轴在单次口服RU4864mg/kg后的反应。正常人在8pm口服RU486后连续2天8Am的血促肾上腺皮质激素(ACTH)和皮质醇(F)均明显升高(P<0.01,P<0.001),服药后第一天24h尿F亦明显升高(P<0.001)。库欣综合征组服药后连续观察2天上述激素水平无明显改变。正常组服药后连续2天的血F,ACTH及24h尿F较服药前所增加的百分比均明显高于库欣综合征组(P<0.05)。正常人和库欣综合征患者的垂体肾上腺轴对RU486有明显不同的反应。我们认为一次法RU486激发试验诊断库欣综合征优于小剂量地塞米松抑制试验,可能有临床应用价值。
The pituitary adrenal axis response to a single dose of RU486 (4mg/kg) was observed in 10 normal subjects and 14 patients with Cushing's syndrone. It was found that after RU486 was given at 20:00, the 8Am levels of plasma ACTH and plasma cortisol were increased significantly (P<0.01,P<0.001) on the next two consecutive days and 24h urine cortisol was increased remarkably(P<0.01)on the next day. In Cushing's syndrome group, the administration of a single dose of RU486 induced no significant changes in the a forementioned hormone levels (P>0.05) on the next two consecutive days. In normal subjects, the increased perceatages of plasma contisol. ACTH and urine cortisol on the two consecutive days after taking RU486 were significantly higher than those in the Cushing's group(P<0.05). There was a significantly different response of pituitary adrenal axis to RU486 between normal subjects and Cushing's group. The results suggest that RU486 stimulating test may have clinical value in diagnosing Cushing's syndrome.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1997年第2期104-107,共4页
Chinese Journal of Endocrinology and Metabolism