摘要
目的检测雌激素受体(ER)、孕激素受体(PR)在子宫内膜异位症(EMS)病人异位内膜和在位内膜中的表达,探讨二者在EMS发生发展中的作用。方法采用免疫组织化学PV-9000法分别检测84例EMS病人的异位内膜和44例EMS病人的在位内膜组织中ER和PR的表达,以32例子宫肌瘤病人正常子宫内膜作对照。结果EMS异位内膜组织中ER、PR的表达及ER/PR比值明显低于正常内膜组织和EMS在位内膜组织,差异均有统计学意义(F=5.92～11.43,q=3.01～3.52,P<0.05);而EMS在位内膜组织ER、PR表达及ER/PR比值明显高于正常内膜组织,差异亦均有显著性(q=2.98～3.14,P<0.05)。结论ER、PR在EMS异位内膜和在位内膜中的异常表达,可能与EMS的发生发展有关。
Objective To detect the expression of ER, PR in ectopic and eutopic endometrium in endometriosis. Methods The expression of ER and PR in ectopic endometrium （n=84） and eutopic endometrium （n=44） in endometriosis as well as normal endometrium （n=32） were detected by PV-9000 of immunohistochemistry. Results The expression of ER and PR and ER/PR ratio in ectopic endometrium were significantly lower than that in eutopic and normal endometrium （P〈0.05）, The expression of ER and PR and ER/PR ratio in eutopic endometriums were significantly higher in normal endometrium （P〈0.05）. Conclusion The abnormal expression of ER, PR and ER/PR in ectopic and eutopic endometrium of endometriosis could be relevant to the development and progress of endometriosis.
出处
《青岛大学医学院学报》
CAS
2007年第6期485-486,共2页
Acta Academiae Medicinae Qingdao Universitatis
基金
山东省自然科学基金项目(Y2003C01)
