病程对1型糖尿病血脂、血尿酸水平及并发MS的影响

INFLUENCE OF THE COURSE OF TYPE 1 DIABETES ON PATIENT'S LIPID,URIC ACID AND METABOLIC SYNDROME

目的探讨病程对1型糖尿病病人血脂、血尿酸水平及并发代谢综合征(MS)的影响。方法随机选取144例1型糖尿病病人,依据病程长短分为A组(病程<5年)、B组(病程5～15年)、C组(病程>15年),分析比较3组病人体质量指数(BMI)、血总胆固醇(TC)、三酰甘油(TG)、血尿酸(UA)水平及并发MS情况。结果C组病人BMI明显高于A组,差异有显著性(F=3.449,q=3.656,P<0.05);C组病人血TC、TG、UA水平及MS发生率明显高于B组,B组明显高于A组,差异有显著性(F=5.60～90.25,q=3.122～18.988,P<0.01;χ2=8.52,P<0.05)。结论随着病程延长,1型糖尿病病人BMI、血TC、TG、UA水平逐渐升高,MS发生率增加。

Objective To investigate the relationship between the course of type 1 diabetes and lipid, uric acid levels as well as metabolic syndromes （MS）. Methods This study consisted of 144 patients, who were divided into groups A, B and C according to the courses of disease. Group A （〈 5 years）; groupB （5-15 years）; and groupC （〉15 years）. The body mass index （BMI）, serum levels of TC, TG, UA and the prevalence of MS were compared among the three groups. Results The BMI of group C was higher than group A （F=3. 449,q=3. 656,P〈0.05）. The serum level of TC, TG, UA and MS of group C were higher than those of groups C, and those of group B were higher than group A （F≈5.60-90.25,q=3,122-18. 988,P〈0.01; χ^2 =8.52,P〈0.05）. Conclusion BMI, the serum levels of TC, TG, UA and the prevalence of MS were increased with the increase of course-duration of type 1 diabetes.