血浆骨调素水平与系统性红斑狼疮活动性的关系

RELATIONSHIP BETWEEN SERUM LEVELS OF OSTOEPONTIN AND THE REACTIVENESS OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

目的研究系统性红斑狼疮(SLE)病人血浆骨调素(OPN)水平与SLE活动性的关系。方法采用酶联免疫吸附试验(ELISA)检测了90例SLE病人及30例对照者血浆OPN的水平,观察OPN与SLE疾病活动指数标准(SLEDAI)及其他疾病活动指标[抗双链-DNA(抗ds-DNA)抗体,补体C3和C4,红细胞沉降率]的相关性。结果SLE病人血浆OPN水平显著高于正常对照组(t=4.748,P<0.01);狼疮肾炎(LN)组OPN高于非LN组(t=3.163,P<0.01);活动组血浆OPN水平较非活动组明显增高(t=3.305,P<0.01)。血浆OPN水平与抗ds-DNA抗体滴度和SLEDAI评分呈正相关(r=0.573、0.315,P<0.01),与C3呈负相关性(r=-0.348,P<0.05),与C4、红细胞沉降率无显著相关性(P>0.05)。结论SLE病人OPN水平升高,且与SLE活动性呈显著正相关,检测血浆OPN水平可以作为诊断SLE活动性的有效指标之一。

Objective To investigate the relationship between serum levels of ostoepontin （OPN） and disease reactiveness in patients with systemic lupus erythematosus （SLE）. Methods The enzyme-linked immunoabsorbent assay （ELISA） was used to measure the serum OPN in 90 SLE patients and 30 healthy adults. Activity Index （SLEDAI） and laboratory parameters such as levels of anti dsDNA antibody, compliment C3 and C4 were checked as well. Results Serum OPN of SLE patients was significantly higher than that of the healthy adults （t=4. 748,P〈0.01）. Higher serum levels of OPN were also found in patients with lupus nephritis （LN） compared with that in nonLN patients （t= 3. 163 ,P,〈0.01）, as well as in patients with active disease compared with that inactive （t=3. 305, P〈0. 01）. The OPN levels measured at active stage correlated positively with SLEDAI score and anti-dsDNA antibody titer （r=0. 573,0. 315;P〈0.01）, negatively with C3（r=-0. 348,P〈0.05）, but not correlated with C4 and erythrocyte sedimentation rate （P〉0.05）. Conclusion Serum levels of OPN can be used as an effective index to refleet the activity of SLE.