胃窦部腺癌和慢性胃炎组织 Maspin 的表达

Comparative studies of tumor suppressor gene Maspin expression in gastric antrum adenocarcinoma and chronic gastritis

采用免疫组化方法，取胃窦部粘膜上皮，对２９例慢性胃炎和腺癌组织肿瘤抑制基因Ｍａｓｐｉｎ的表达变化进行比较研究。结果：Ｍａｓｐｉｎ蛋白在慢性胃炎中的表达率为５３％（８／１５），在胃癌中的表达率为２１％（３／１４），两者差异有显著性（Ｐ＜０．０５），且Ｍａｓｐｉｎ蛋白在慢性胃炎和腺癌病变中的免疫反应类型不同，前者免疫反应部位以胞浆为主，后者主要位于胞核。提示：Ｍａｓｐｉｎ的表达是胃癌癌变早期阶段的一种重要分子学改变。

Comparative studies were performed on tumor suppressor gene Maspin expression in 29 subjects with chronic gastritis and adenocarcinoma in gastric antrum with immunohistochemical method.Results:Maspin protein expression rate was 53%(8/15) in chronic gastritis and 21% (3/14) in gastric antrum adenocarcinoma.The difference was significant (P<0.05).Different immunoreactivity patterns for Maspin protein were observed in chronic gastritis and adenocarcinoma.The immunoreactivity was chiefly located in the cytoplasm in chronic gastritis,while in adenocarcinoma,it was chiefly located in the nucleus.Higher rate of Maspin protein expression in epithelium with chronic gastritis suggested that Maspin protein expression might be one of the important molecular changes in the early stage of gastric carcinogenesis.