阿斯匹林对突发性耳聋患者血浆TXB_2、6-K-PGF_(1a)的影响

Influence of aspirin on plasma balance between TXB 2 and 6 K PGF 1a in sudden deafness

用酶标记免疫法测定３０例突发性耳聋（突聋）患者发病期血浆血栓素Ｂ２（ＴＸＢ２）和６酮前列腺素Ｆ１ａ（６ＫＰＧＦ１ａ）的含量，并对比不同治疗方法对血浆ＴＸＢ２和６ＫＰＧＦ１ａ的影响。结果：突聋患者ＴＸＢ２、ＴＸＢ２／６ＫＰＧＦ１ａ（Ｔ／Ｐ）比值明显增高，６ＫＰＧＦ１ａ显著降低；阿斯匹林治疗后，ＴＸＢ２及Ｔ／Ｐ比值接近正常水平，６ＫＰＧＦ１ａ无明显变化，常规治疗组各项指标均无显著性变化。提示：突聋患者可能存在Ｔ／Ｐ动态平衡失调，而对Ｔ／Ｐ平衡失调的突聋患者加用阿斯匹林治疗可能提高疗效。

Plasma concentrations of 6 keto PGF 1a and thromboxane B 2(TXB 2) were measured in 30 sudden deafness patients with enzymoimmunoassay,and the effects of different therapies on plasma levels of 6 keto PGF 1a and TXB 2 in these cases were compared.It was observed that TXB 2 and the ratio of TXB 2 to 6 keto PGF 1a (T/P) significantly increased,while 6 keto PGF 1a significantly decreased in the sudden deafness patients.TXB 2 and T/P ratio significantly decreased or tended to be normal, whereas 6 keto PGF 1a had no change after asiprin therapy.However TXB 2 and 6 keto PGF 1a and T/P ratio had no change in the conventional therapy.The study suggested that TXB 2 and 6 keto PGF 1a imbalance may play an important role in the pathogensis of sudden deafness.Aspirin therapy may improve the hearing of the sudden deafness patient with T/P ratio equilibrium.