麻醉剂量羟甲芬太尼对大鼠血浆皮质酮、皮质醇和抗利尿激素含量的影响

EFFECTS OF OHMEFENTANYL AT ANESTHETIC DOSE ON PLASMA LEVELS OF CORTICOSTERONE, CORTISOL AND ANTIDIURETIC HORMONE IN RATS

麻醉剂量羟甲芬太尼对大鼠血浆皮质酮、皮质醇和抗利尿激素含量的影响金昔陆金文桥周德和李桂芬池志强（中国科学院上海药物研究所，上海２０００３１）羟甲芬太尼（ｏｈｍｅｆｅｎｔａｎｙｌ，ＯＭＦ）是我室研制的芬太尼（ｆｅｎｔａｎｙｌ，ＦＥＮ）衍生物，从受体水...

Ohmefentanyl (OMF) is a new μ opioid receptor agonist with high affinity and selectivity, and possesses anesthetic activity. With radioimmunoassay, the plasma levels of cortisol(C), corticosterone (CS) and antidiuretic hormone (ADH) in rats were measured. The results indicated that no significant differences in the plasma C, CS and ADH levels were observed between the saline control group and the OMF treated group. Trauma (bone crush injury) increased significantly the plasma CS level. However, pretreatment with OMF 4 0 μg·kg -1 reduced markedly the CS plasma levels in trauma treated rats. The results suggest that OMF anesthesia itself showed no obvious effect on the plasma concentration of C, CS and ADH, but blocked the hormoral stress responses such as the increment of plasma CS level caused by trauma stimulus.