^(89)SrCl加博宁治疗多发性骨转移癌骨痛30例临床观察

CLINICAL OBSERVATION ON MULTIPLE MALIGNANT BONE METASTASIS TREATED WITH ^(89)SrCl AND PAMIDRONATE DISODIUM-NEPTUNUS AMONG 30 CASES

目的:分析应用89SrCl高度亲骨性核素结合博宁治疗多发性骨转移癌骨痛的疗效。方法:对30例转移性骨癌疼痛患者,采用89SrCl结合博宁的方法进行治疗;结果:疼痛完全缓解15例,部分缓解13例,无效2例,总有效率93.3%。多数患者在给药后一周至10天逐渐起效,止痛时间持续4周以上。治疗后全身状况kamofsky评分提高到63.2分,与治疗前比较P<0.01,有显著差异。结论:89SrCl高度亲骨性核素结合博宁是治疗转移性骨癌较为有效的和可行的方法。

Objective： To analyse the curative efectiveness on multiple malignant bone metastasis patients treated with radioactive nuclide Sgsrcl and Pamidronate Disodium- Neptunus among 30 cases. Method： 30 malignant bone metastasis patients were treated with 89SrC1 and Pamidronate Disodium- Neptunus.Results： Bone ache vanished among 15 cases, 13one＇ released among 13 cases, and non - response among 2 eases.The total effective rate was 93.3% .For most patient, effectiveness was showed in 7 - 10 day after being treated, and could be lasted over 4 weeks. The whole body Kamofsky score was improved to 63.2 compared with that of pre - treatment. The difference was statistics （P 〈 0.01 ） . Conclusion： It is an effective and practicable method to treat multiple malignant bone metastasis patients with radioactive nuclide 89SrC1 and Pamidronate Disodium - Nep- tunus.